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Alpha-lipoic Acid upfu (1077-28-7)

Alpha-lipoic acid / thioctic acid poda kemikari-yakafanana nemakemikari inonzi antioxidant. Mbiriso, chiropa, itsvo, sipinashi, broccoli, uye mbatatisi zvinhu zvakanaka zvealpha-lipoic acid / thioctic acid. Iyo inogadzirwawo murabhoritari kuti ishandiswe semushonga. Alpha-lipoic acid / thioctic acid inowanzo kutorwa nemuromo wechirwere cheshuga uye zviratidzo zvine chekuita nemitsipa zvechirwere cheshuga zvinosanganisira kuputika, kurwadziwa, uye kupera mukati memakumbo nemaoko. Inopihwa zvakare sejekiseni mutsinga (ne IV) kune izvi zvakafanana zvinoshandiswa. Mahombekombe epamusoro ealpha-lipoic acid / thioctic acid anotenderwa kuGerman kwekurapwa kweaya maratidziro ane hukama nemitsipa.

Gadzira: Batch Kugadzira
nhuri: 1KG / bhegi, 25KG / dhiramu
Wisepowder inokwanisa kugadzira uye kupa huwandu hukuru. Zvese zvinogadzirwa pasi pecGMP mamiriro uye yakasimba yemhando yekudzora system, ese magwaro ekuyedza uye sampuro iripo.
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Alfa-lipoic Acid poda Base Ruzivo

 

zita Alfa-lipoic Acid poda
CAS 1077-28-7
Purity 98%
Kemikari zita (+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -cy-Lipoic Acid
Synonyms DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipothion; NSC 628502; NSC 90788; Protogen A; Thioctsan Tioctacid;
Molecular Formula C8H14O2S2
Molecular Weight 206.318 g / mol
Melting Point 60-62 ° C
InChI Key AGBQKNBQESQNJD-UHFFFAOYSA-N
fomu simba
Kuonekwa Chiyero cheYero kune Yero
Hafu Hupenyu Maminitsi makumi matatu kusvika 30 awa
Solubility Soluble muChloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage Condition Kuoma, kusviba uye pa0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki) kana -20 C kwenguva refu (mwedzi kusvika makore).
kunyoresa Iyo mafuta-metabolism inomutsa.
Rugwaro rweKwayedza Available
Alfa-lipoic Acid
Mufananidzo weupfu
Chiedza Chiedza

 

Chii chinonzi Alpha-lipoic Acid?

Alpha-lipoic acid is antioxidant inotorwa kubva ku caprylic acid. Mamwe mazita arwo ALA, lipoic acid, Biletan, Lipoicin, Thioctan, nezvimwewo zita rayo remakemikari 1,2-dithiolane-3-pentanoic acid kana thioctic acid. Iyo inhengo ye organosulfur uye inogadzirwa mumuviri wevanhu nemhuka. Kugadzirwa kwaro kunoitika kubva kuoctanoic acid uye cysteine ​​sesarufa sosi. Icho chinhu chakakosha cheiyo aerobic metabolism mumuviri. Inowanikwa mune yese sero uye inobatsira kugadzira simba kubva paglucose.

Iyo ine akawanda maseru uye mamorekuru mashandiro, nekuda kweayo antioxidant kugona. Iyi antioxidative chiito chealpha-lipoic acid yakasimudza kufarira kwayo kuti ishandiswe sekuwedzera kwekuvaka muviri. Inoshandiswa zvakare seanorapa mumiririri. Inogona kunge iri nzira yekurapa mune chirwere cheshuga, kurasikirwa uremu, neuropathy inokonzerwa nekuda kweshuga, kupora kwemaronda, kugadzirisa mamiriro eganda, nezvimwe.

Iyo alpha-lipoic acid poda ine hafu yeupenyu yemaminitsi makumi matatu kusvika paawa rimwe. Iyo inogadzikana zvishoma mu chloroform, dimethyl sulfoxide (DMSO), uye methanol. Inogona kuwanikwa kubva kusipinachi, mbiriso, broccoli, mbatatisi, nyama yakaita sechiropa neitsvo.

Iyo yakanyanya dhosi iyo munhu mukuru anogona kutora pazuva ndeye 2400mg.

 

Alpha-lipoic Acid Inoshanda Sei?

Alpha-lipoic acid ine antioxidant zvivakwa. Zvinoreva kuti inogona kurwisa zvine mutsindo mahara mumuviri uye kudzikamisa zviitiko zvakaita sekukwegura kwemasero uye kubatsira kuchengetedza maseru ane hutano.

Iyo inogadzirwa mune mitochondria uye inoshanda seyakakosha cofactor yekutyora ma enzyme uye zvinovaka muviri. Iyo zvakare inobiridzira simbi ion uye inoderedza iyo yakasanganiswa fomu yemamwe antioxidants senge vhitamini C, Vitamin E, uye glutathione. Alpha-lipoic acid inodikanwa kudzora inoshanda oxygen mhando.

Alpha-lipoic acid inokurudzirawo antioxidant defense system. Inoita izvi kuburikidza neNrf-2-yakagadziriswa antioxidant gene expression. Iyo zvakare inogadzirisa magene anoda iyo peroxisome proliferator kuti iite iwo.

Alpha-lipoic acid inodzivirirawo nyukireya kappa B. Inoita kuti AMP-inoshanda protein kinase (AMPK) mumasekete emhasuru uye inokonzeresa zviito zvakasiyana-siyana zvemagetsi.

Kune maviri mafomu ealpha-lipoic acid. Izvo zvine oxidized lipoic acid (LA) uye yakaderedzwa dihydrolipoic acid (DHLA). DHLA inogadzirwa mumitochondria ine masero mumuviri. Izvi zvinogoneka nicotinamide adenine dinucleotide hydrogen (NADH) uye lipoamide dehydrogenase. Izvi zvinhu zviviri zvinobatsira mune ino shanduko yekuita.

Mumasero anoshaya mitochondria, alpha-lipoic acid inogona kudzikiswa kuita DHLA kuburikidza nicotinamide adenine dinucleotide phosphate (NADPH). Ichi chiito chinobatsirwa ne glutathione uye thioredoxin reductases.

Alpha-lipoic acid ine yakasarudzika chivakwa chinoita kuti ive yakasiyana ne glutathione. Kunyange iri chete yakaderedzwa fomu ye glutathione iri antioxidant, ese ari maviri akaderedzwa uye asiri-akaderedzwa mafomu ealpha-lipoic acid ane simba antioxidants.

Alpha-lipoic acid inobatanidzwawo mukugadzirisa mapuroteni ane oxidized uye inogona kubatsira mukugadzirisa kwejeneti yekunyora.

Alpha-lipoic acid ine anti-kupisa zvinhu zvakare. Inomisa kappa B kinase, enzyme iyo inoita kuti NF-kB, iyo inogadzirisa inoputi cytokines [1].

 

Nhoroondo yeAlpha-lipoic Acid

Alpha-lipoic acid yakawanikwa muna 1937 naSnell. Panguva iyoyo, vesaenzi vaidzidza mhando yebhakitiriya yaishandisa muto wembatata pakubereka. 1n 1951, yaive yakasarudzika naReed. Yekutanga kiriniki yekushandisa yakatanga kuGerman muna 1959 yekurapa chepfu nekuda kwekufa kwekuvhara howa.

Ruzivo maererano nekushandiswa kwe alpha-lipoic acid uye kushanda kwayo harisati rapera. Kushandiswa kwaro mukurapa hakuna kusimbiswa neDFA. Asi pamusoro pemakore, yakawana mukurumbira sekuwedzera.

 

Ndeapi Iwo Mhedzisiro Mhedzisiro yeAlpha-lipoic Acid?

Kufanana nemimwe mishonga yakawanda, alpha-lipoic acid inewo mimwe mhedzisiro.

Mimwe yemhedzisiro inowanzoitika yealpha-lipoic acid ndeiyi:

  • kurwadziwa nemusoro
  • Kushungurudza
  • Nausea
  • Kudzora
  • Hypersensitivity
  • Chiedza-musoro
  • Iko shuga shoma
  • Kushanda kweganda
  • Intoxication

Alpha-lipoic acid poda mhedzisiro kune vane nhumbu uye vanoyamwisa vanaamai hazvizivikanwe. Saka zvinokurudzirwa kuti usashandise izvi kana uine pamuviri kana kuyamwa.

 

Ndeapi mabhenefiti eAlpha-lipoic Acid?

Pane zvakawanda zvakanakira alpha-lipoic acid. Vari:

 

Migumisiro paAlzheimer's Disease

Iyo alpha-lipoic acid poda ine mukana wekunonoka kutanga kana kunonoka kufambira mberi kwechirwere cheeurodegenerative. Chidzidzo chakaitwa pavarwere vapfumbamwe vane chirwere cheAlzheimer. 600mg yeAlpha-lipoic acid yakapihwa zuva nezuva kwemwedzi gumi nembiri [12]. Yakanga ichikwanisa kudzikamisa kugona kwevarwere ava. Yayo antioxidant chivakwa inogona kudzora mamiriro uye inogona kutoita seyeuroprotective mumiriri.

 

Migumisiro pane chirwere cheshuga

Alpha-lipoic acid inogona kubatsira kudzikisa mashuga eropa mune varwere vane chirwere cheshuga. Sezvo yayo antioxidant zvivakwa inogona kubvisa mahara radicals mumuviri, inogona kubatsira kurapa kukuvara kwemasero anokonzerwa nechirwere cheshuga. Inogona zvakare kuvandudza insulin kusagadzikana mune vanhu vane chirwere cheshuga. Inogona kudzivirira kufa kwemasero eBeta uye inogona kutosimudzira kutora kweglucose uye kudzikisira pasi matambudziko eshuga, kunyanya chirwere cheshuga chirwere cheuropathy [3].

 

Migumisiro paStroke

Alpha-lipoic acid ine neuroprotective kugona. Maitiro ayo antioxidant anogona zvakare kubatsira mukuwedzera kweiyo neuron muuropi iyo yakatambura sitiroko. Chidzidzo chakaitwa pamakonzo ane ischemic stroke avo vakapihwa alpha-lipoic acid yakaratidza kuvandudzwa kwavo mamiriro [4]. Nekudaro, zvinogona kubatsira kuvandudza mamiriro evarwere ve stroke.

 

Migumisiro pakukwegura

Iyo alpha-lipoic acid poda inogona zvakare kubatsira kubatsira kudzora kukwegura kweganda. Alpha-lipoic acid inogona kupa imwe elektroni kune inokuvadza-ganda uye kukwegura-kunokonzera chinhu chinoshanda uye kuzvisimbisa pachayo. Nenzira iyi inogona kumisa kuchembera uye inogona zvakare kuzadza chinzvimbo cheakashomeka antioxidant chinhu [5]. Izvi zvinogona zvakare kubatsira kupokana nekukuvara kunokonzerwa nezvinhu zvakasiyana.

 

Migumisiro yeMercury Poisoning uye Autism

Alpha-lipoic acid inogona kupfuudza iyo yeropa-brain barriers. Iyo inogona kutoshandiswa kushambadza mercury yakasungirirwa kumaseru ehuropi kuitira kana mercury ine chepfu [6]. Inogona kuunganidza iyo yakasungwa mercury muropa kubva uko mamwe ma chelator maimendi senge dimercaptosuccinic acid (DMSA) kana methylsulfonylmethane (MSM) inogona kuendesa iyo mercury zvakachengeteka kupinda muitsvo uyezve kubuda mumurini. Sezvo kana DMSA kana MSM isingayambuke ropa-brain barriers, kushandisa alpha-lipoic acid neDMSA kunogona kubatsira kubvisa zvakachengeteka mercury. Izvi zvinogona zvakare kubatsira kurapa autism sevana vane autistic vane mwero wakakwirira wemekiyuri muhuropi hwavo zvichienzaniswa neyakajairika. Zvisinei, zvidzidzo maererano neizvi zvishoma.

 

Migumisiro yeAnemia

Chidzidzo chakaitwa kuvarwere vane chirwere cheitsvo chekupera-chikamu neanemia uko alpha-lipoic acid yakapihwa varwere [7]. Yakaratidza kuve inokwanisa seyrythropoietin mukuwedzera iwo mazinga ehemoglobin pasina zvinokuvadza. Nekudaro, zvinogona kubatsira kurapa kupererwa neropa kunokonzerwa nekuguma-nhanho renal kutadza. Zvinogona zvakare kubatsira mune zvehupfumi.

 

Mhedzisiro seAntioxidant

Sezvo iyo alpha-lipoic acid poda iri antioxidant, ine mabhenefiti mazhinji uye inogona kubatsira nemhando zhinji dzemamiriro mumuviri.

 

Mhedzisiro yeNeurotoxicity Nekuda kweAlcoholism

Doro rinogona kukonzera kusagadzikana kwehuropi nekuda kweiyo oxidative kusagadzikana. Alpha-lipoic acid inogona kubatsira kurapa neurotoxicity nekuda kwedoro. Inogona kudzivirira protein oxidation inoitika mukutora ethanol [8].

 

Mhedzisiro pakurera uremu

Alpha-lipoic acid inogona zvakare kuve yekuwedzera yakanaka yekubatsira mukudzora huremu hwevanhu vakafutisa uye vakafutisa [9]. Iyo ine mashoma mhedzisiro mhedzisiro kana ichienzaniswa neimwe yekuremerwa kurasikirwa mishonga uye ine antioxidants iyo inogona kubatsira mukuchengetedza munhu akagwinya.

 

Contraindications

Iko hakuna kuwanda kwedzidzo pane zvinopesana zvealpha-lipoic acid. Nekudaro, vamwe varwere vane mimwe mamiriro vanofanira kungwarira vasati vashandisa chinhu ichi uye kubvunza chiremba vasati vaishandisa.

Mimwe yemamiriro aya ndeaya:

  • Chiropa chechiropa
  • Kunyanyisa kunwa doro
  • Utachiona chirwere
  • Kushayikwa kweTiamine

 

Kudyidzana Kwezvinodhaka naAlpha-lipoic Acid

Iko hakuna ruzivo rwakawanda pamusoro pekudyidzana kwealpha-lipoic acid nemimwe mishonga. Asi mimwe mishonga yakanakisa kudzivirirwa neiyi yekuwedzera.

Mimwe yemishonga iyi ndeiyi:

Hypoglycemic Zvinodhaka - Alpha-lipoic ine shuga yeropa inoderera kugona. Mune zvimwe zviitiko zvinogona kukonzera insulin autoimmune syndrome, inotungamira ku hypoglycemia. Saka kuishandisa ne hypoglycemic zvinodhaka zvinogona kukonzera kukurumidza hypoglycemia iyo inogona kuve ine njodzi.

Mishonga yehutachiona - Alpha-lipoic acid inogona kudzikisa huwandu hwetachiona mahormone. Saka kuongorora kwakakodzera kunodiwa kana kuchishandiswa levothyroxine.

 

Ndekupi Kwaunga Tenga Alfa-lipoic Acid muna 2021?

Unogona kutenga alpha-lipoic acid powder zvakananga kubva kune alpha-lipoic acid kambani inogadzira. Inowanikwa mune yakasimba solid yero kune yero hupfu. Iyo yakarongedzwa mupakeji ye1 kg pakiti uye 25kg padhiramu. Nekudaro, izvi zvinogona kushandurwa zvinoenderana nezvinodiwa nemutengi.

Inoda kuchengetwa patembiricha ye0 kusvika 4 ° C yenguva pfupi uye -20 ° C yenguva refu. Inoda inotonhorera, ine rima, uye yakaoma nzvimbo yekuchengetera kuti irege kusangana nemamwe makemikari munharaunda. Ichi chigadzirwa chinogadzirwa kubva kune akakosha zvigadzirwa zvichitevera zvakakodzera maprotocol.

 

Referensi Dzakataurwa

  1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Alpha-lipoic acid ine anti-anogumbura mhedzisiro pane lipopolysaccharide-yakasimudzira rat mesangial maseru kuburikidza nekudzivirira kweiyo nyukiliya factor kappa B (NF-κB) inoratidzira nzira. Kupisa, 38(2), 510-519.
  2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid senzira nyowani yekurapa kwechirwere cheAlzheimer-A 48 mwedzi yekutevera yekuongorora. In Neuropsychiatric Dambudziko Rekubatanidza Nzira(mapeji 189-193). Springer, Vienna.
  3. Laher, ini (2011). Chirwere cheshuga uye alpha-lipoic acid. Frontiers mune chemacology, 2, 69.
  4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Alpha-lipoic acid kurapwa ndeye neurorestorative uye inosimudzira inoshanda kupora mushure mekurohwa mumakonzo. Molecular uropi, 8(1), 1-16.
  5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Mhedzisiro ye α-Lipoic Acid paKuvandudza kweGanda revanhu Rakaenzana Uchishandisa Pumpless Skin-on-a-Chip Model. International Journal of Molecular Sciences, 22(4), 2160.
  6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Insights pane alpha-lipoic uye dihydrolipoic acids seinovimbisa vanopwanya yekushushikana nekushushikana uye vanogona chelators mu mercury toxicology. Zvinyorwa zve inorganic biochemistry, 195, 111-119.
  7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Basa reAlpha-lipoic acid mukutarisira kweanemia mune varwere vane chisingaperi itsvo kutadza kuri kuita hemodialysis. Yepasi rose magazini yeephrology uye renovascular chirwere, 6, 161.
  8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Alpha-lipoic acid inodzivirira ethanol-inosimudzira protein oxidation mune mbeva hippocampal HT22 maseru. Neuroscience Letters, 328(2), 93-96.
  9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alpha-lipoic acid (ALA) sekuwedzera kwekudzikira uremu: mhedzisiro kubva ku meta - ongororo yemiedzo yakasarudzika. Kuwedzera kwekuongorora, 18(5), 594-601.

 

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