Products

Fisetin Poda (528-48-3)

Fisetin yakajairika botanical polyphenol uye flavonoid inowanikwa mumhando dzakasiyana dzemiti, michero nemiriwo zvinosanganisira mahabhurosi, maapuro, persimmon, hanyanisi uye magaka. Fisetin inoonekwa seyakagadzwa pigment ichipa michero yakawanda uye miriwo, senge sitirobheri, iine hunhu uye chimiro. Fisetin ine akafanana akafanana mamorekuru chimiro seinonyanya kufarirwa chirimwa flavonoid uye chikafu chinowedzera Quercetin. Kusiyana neQuercetin, zvakadaro, Fisetin anogona kunge ari senolytic uye pamwe iri rimwe remasimba ane simba kwazvo anozivikanwa.

Gadzira: Batch Kugadzira
nhuri: 1KG / bhegi, 25KG / dhiramu
Wisepowder inokwanisa kugadzira uye kupa huwandu hukuru. Zvese zvinogadzirwa pasi pecGMP mamiriro uye yakasimba yemhando yekudzora system, ese magwaro ekuyedza uye sampuro iripo.

1.Chii chinonzi Fisetin?

2.The Mechanism Of Action yeFisetin: Fisetin inoshanda sei?

3.Chikafu chipi chine Fisetin?

4.Ndezvipi zvinobatsira zveFisetin?

5.Fisetin Vs Quercetin: is fisetin yakafanana nequercetin?

6.Fisetin Vs Resveratrol: fisetin iri nani pane resveratrol?

7.Fisetin uye kuora muviri

8.Yakawanda sei fisetin yandinofanira kutora: The fisetin dosage?

9.Ndeipi mhedzisiro yefisetin?

10.Fisetin powder uye fisetin zvinowedzera paIndaneti

 

Fisetin Chemical Base Ruzivo Base Ruzivo

zita Fisetin Upfu
CAS 528-48-3
Purity 65%, 98%
Kemikari zita 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Synonyms 2- (3,4-dihydroxyphenyl) -3,7-dihydroxychromen-4-imwe, 3,3 ′, 4 ′, 7-Tetrahydroxyflavone, 5-Deoxyquercetin, Natural Brown 1, CI-75620, NSC 407010, NSC 656275, BRN 0292829, Cotinin, 528-48-3 (isina mvura)
Molecular Formula C15H10O6
Molecular Weight 286.24
Melting Point 330 ° C (chidimbu)
InChI Key GYHFUROKCOMWNQ-UHFFFAOYSA-N
fomu simba
Kuonekwa Powder Yero
Hafu Hupenyu /
Solubility Inogadziriswa ku 100 mM muDMSO uye ku 10 mM mune ethanol
Storage Condition -20 ° C kwenguva yakareba
kunyoresa Fisetin isimba guru sirtuin activating compound (STAC), antiinfigueatory uye anticancer mumiririri.
Rugwaro rweKwayedza Available

 

Flavonoid polyphenols inowanzoshandiswa kune yavo antioxidant zvinhu. Chitubu chavo chikuru michero nemiriwo zvinodyiwa nguva dzose, nemamiriyoni pasi rose. Nekuda kwehutano hwavo hwakanaka, flavonoids zvakare yave yakakosha zvinongedzo mune zvakasiyana zvekudya zvinowedzera, kunyanya resveratrol. Zvidzidzo zvenguva pfupi yapfuura zvakawana flavonoid itsva inonzi fisetin, iyo inofungidzirwa kuti ndiyo ine simba pakati pemamwe maflavonoid anoshandiswa sechikafu chekuwedzera. Fisetin poda kana Fisetin supplements kubvira zvawedzera mukudiwa nekuda kwehutano hwavo.

 

Chii chinonzi Fisetin?

Fisetin iflavonoid polyphenol inoshanda seyero pigment muzvirimwa. Pakutanga yakawanikwa muna 1891, fisetin inowanikwa mumichero yakawanda nemiriwo yakadai sepersimmon nemastrawberries. Kunyangwe zvavepo kwenguva yakareba, ichangoburwa iyo fisetin mabhenefiti akawanikwa uye akaita kuti ive pachena kana ichienzaniswa nezvimwe zvinowedzera. Uyezve, yakanga iri mishonga inogona kubatsira yefisetin powder iyo yakakurudzira tsvakurudzo munyaya yacho. Kunyangwe zvakadzidzwa uye mabhenefiti efisetic nefisetin mhedzisiro akaonekwa, pachine zvakawanda izvo masayendisiti haana kukwanisa kunzwisisa nezve flavonoid.

 

Iyo Mechanism Yekuita kweFisetin: Fisetin inoshanda sei?

Fisetin poda inoshanda nenzira dzakawanda mumuviri wemunhu. Fisetin inonyanya kushanda pamazinga e antioxidants mumuviri uye iyi ndeimwe yemabhenefiti ayo makuru. Inorwisana nemahara radicals, ayo asina kugadzikana ions anozotora chikamu mukukuvadza kwemakemikari maitiro kukuvadza muviri. Fisetin's antioxidant zvimiro zvinoibvumira kumisa aya emahara radicals uye nekudaro, kuderedza iyo oxidative kusagadzikana iyo muviri uri pasi.

Imwe nzira yekuita yefisetin ndeyekuti inovharira nzira yeNF-KB. Iyi nzira yakakosha pakugadzirwa uye kuburitswa kwepro-inflammatory cytokines uye pakupedzisira, kuzvimba. NF-KB inzira inokonzeresa-kuzvimba iyo inoita kuti kunyoreswa kwejeni kugadzirise mapuroteni anokonzera. Kana yanyanya kushandiswa, iyo NF-KB nzira inoita basa rakakosha mukukura kwegomarara, allergies, uye autoimmune zvirwere. Fisetin poda inovhara nzira iyi, saka, ichiita senge anti-inflammatory supplement.

Fisetin powder inovharawo chiito chemTOR nzira. Iyi nzira, senge NF-KB nzira, inobatanidzwa mukukura kwegomarara, chirwere cheshuga mellitus, kufutisa, uye neurodegenerative zvirwere. mTOR nzira inokonzeresa kuti masero avhunduke paanenge achinetseka kuti asangane nezvinodiwa zvesimba renzira, zvichikonzera kuwanda kwebasa pamaseru. Zvinoreva izvi ndezvekuti maseru ari kushanda zvakanyanya uye kugadzira tsvina yemetabolism asi hapana nguva yakakwana yekuchenesa tsvina zvichikonzera kuunganidzwa kwemarara. Izvi zvinogona kukanganisa hutano hweserura uye kuvharika kweiyi nzira nefisetin yekuwedzera ndeyekuti fisetin inobatsira sei kubata kufutisa, chirwere cheshuga, uye cancer.

Kunze kweiyi nzira huru dzekuita, fisetin inokwanisawo kuvharidzira basa re lipid-degrading enzymes, lipoxygenases. Inodzivirirawo matrix metalloproteinases kana mhuri yeMMP yema enzymes. Aya ma enzyme akakosha kuti masero ane kenza akwanise kupinda mune mamwe matukisi, zvisinei, nekushandiswa kwefisetin powder, izvo hazvichagoneki.

 

Ndezvipi zvokudya zvine Fisetin?

Fisetin chirimwa-based flavone iyo inonyanya kutorwa kubva kumaapuro nemastrawberries. Iyo pigment yeyero uye ocher ruvara muzvirimwa, zvichireva kuti michero yakawanda uye miriwo yemuvara iwoyo yakapfuma mufisetin. Fisetin, muzvirimwa, inogadzirwa kubva kuamino acid phenylalanine, uye kuunganidzwa kweflavone iyi mumiti kunoenderana zvakanyanya nenharaunda yechirimwa. Kana chirimwa ichi chikaoneswa kune mapfupi marefu emiranzi yeUV, saka kune kuwedzera kwekugadzirwa kwefisetin. Fisetin poda inogadzirwa kubva pakuparadzaniswa kwefisetin kubva kune zvinotevera zvinorimwa masosi.

 

Miti yekudyara Kuwanda kweFisetin

(μg /g)

Toxicodendron vernicifluum 15000
Strawberry 160
apuro 26
Persimmon 10.6
Onion 4.8
Lotus mudzi 5.8
Mazambiringa 3.9
Kiwifruit 2.0
pichisi 0.6
Cucumber 0.1
Tomato 0.1

 

Ndezvipi zvinobatsira zveFisetin?

Fisetin mabhenefiti akati wandei, uye ese akaonekwa pamhando dzemhuka. Hapana tsvagiridzo yakakwanisa kunyatsoona izvi zvakanaka muvanhu sezvo zvidzidzo zvakawanda zvichiri muchikamu chekiriniki. Mabhenefiti akasiyana efisetin anosanganisira:

 

Anti-Aging

Kuchembera kwemuviri kunoratidzwa nekuwedzera kwemambure mumaseru anesescent, asingachakwanisi kupatsanura. Masero aya anoburitsa zviratidzo zvekuzvimba, izvo zvinokonzeresa matambudziko ekuchembera anowanzoonekwa. Zvirwere zvakawanda zvine chekuita nezera zvinokonzerwa nekuzvimba kunonyangadza mumuviri kunosimudzirwa nemaseru emasero. Fisetin poda inoshandiswa inotarisa masero aya uye inoabvisa kubva mumuviri, nokudaro, kuderedza kuzvimba uye kuderedza kukwegura.

 

Chirwere cheshuga

Mune mhando dzemhuka, fisetin yekuwedzera yakaratidzwa kuderedza mazinga eshuga yeropa zvakanyanya. Izvi zvinokonzerwa nefisetin zvinobva mukukwanisa kweflavonoid kuwedzera mazinga e insulin, kuwedzera glycogen synthesis, uye kuderedza kukwanisa kwechiropa kutanga gluconeogenesis. Chaizvoizvo, fisetin inoshanda panzira yega yega mumuviri inoguma nekugadzirwa kweglucose uye inomisa iyo ichiri kumisa nzira dzinochengeta kana kushandisa glucose muropa.

 

Anti-Kenza

Iyo anti-cancer mhedzisiro yefisetin poda inosiyana zvichienderana nerudzi rwegomarara. Muchidzidzo chakaitwa pagomarara reprostate, fisetin yakakwanisa kuderedza kukura kwegomarara nekuvhara testosterone neDHT receptors, izvo zvakakosha pakukura kwegomarara reprostate. Mune imwe ongororo umo kenza yaidzidzwa yaive kenza yemapapu, fisetin supplements yakakwanisa kuwedzera antioxidants muropa iro rakanga radzikiswa nekushandisa fodya. Fisetin akakwanisawo kuderedza kukura kwekenza yemapapu ne67 muzana ari ega, uye 92 muzana paakasanganiswa nemushonga wechemotherapy. Kana yakashandiswa mugomarara rekoloni, fisetin yakaderedza zvakanyanya kuzvimba kwakabatana nekenza yekoloni. Chidzidzo, zvisinei, hachina kutaura chero mhedzisiro yefisetin pakukura kwegomarara.

 

Neuroprotective

Apo makonzo echikuru ane zera-ane kuderera mucognition akapihwa fisetin yekuwedzera, pakave nekuvandudzwa kukuru muhunyanzvi hwavo hwekuziva uye ndangariro. Mune imwe ongororo, mhando dzemhuka dzakafumurwa kune neurotoxic zvinhu ndokuzopihwa fisetin yekuwedzera. Zvidzidzo zvekuedzwa zvakawanikwa zvisina kumboona kurasikirwa kwekurangarira nekuda kwekuwedzera. Zvakadaro, hazvizivikanwe kana fisetin ichikwanisa kuyambuka mhinganidzo yeropa-uropi nekushanda kwakafanana nembeva yeropa-brain barriers.

Fisetin zvakare neuroprotective mupfungwa yekuti inodzivirira kuvandudzwa kweurourodegenerative kusagadzikana senge Alzheimer's nekudzikisa kuunganidzwa kwemapuroteni anokuvadza muuropi. Saizvozvowo, mbeva dzine ALS dzakaratidza kuvandudzwa kwehutano hwavo uye kurongeka kwemasumbu mushure mekupiwa fisetin powder. Vakararamawo kwenguva refu kupfuura zvaitarisirwa.

 

Cardioprotective

Vatsvakurudzi vakadzidza migumisiro yefisetin powder pamazinga echolesterol emakonzo akadyiswa kudya kwemafuta akawanda. Yese cholesterol uye LDL mazinga akawanikwa akadzikira zvakanyanya nepo HDL mazinga akada kupetwa kaviri. Iyo inofungidzira nzira iyo fisetin inobvisa muviri wecholesterol inotendwa kuwedzera kuburitswa kwayo mu bile. Iyo yakaderedzwa cholesterol, yakazara, ine cardioprotective effect.

Ese mabhenefiti aya efisetin anonongedzera kukurwisa kuchembera uye hupenyu hurefu hunofanirwa kunge hwakakwana kusimudzira zvidzidzo zvekiriniki zvakawanda kuitira kuti komboni igone kubvumidzwa kushandiswa kwemishonga.

 

Fisetin Vs Quercetin: iyo fisetin yakafanana nequercetin?

Quercetin neFisetin zvese zvirimwa flavonoids kana pigment zvinonyatso zivikanwa neapo-anti-inflammatory uye anti-oxidant properties. Iwo ese ari maviri ane akakosha ekudzivirira kuchembera, ayo avanoita nekubvisa maseru maseru kubva mumuviri. Fisetin powder, zvisinei, yakaratidza kubvisa masero nekuwedzera kushanda uye potency kupfuura quercetin.

 

Fisetin Vs Resveratrol: fisetin iri nani pane resveratrol?

Resveratrol ndeye polyphenol iyo zvakare yakakurumbira kune yayo anti-oxidant zvivakwa. Kutora quercetin uye resveratrol kunoguma ne synergistic mhedzisiro pamuviri, kunyangwe quercetin ine simba zvakanyanya pakuyananisa kuzvimba uye kugadzirisa insulin kuramba. Sezvo Fisetin ari nani pakuita mabasa aya pane quercetin, zvinogona kugumiswa kuti fisetin supplement iri nani pane resveratrol inowedzera.

 

Fisetin uye kuderedza uremu

Vatsvakurudzi vakadzidza mhedzisiro yefisetin poda pakuunganidzwa kwemafuta mumuviri uye zvakaonekwa kuti inovhara dzimwe nzira dzekudzikisa kufutisa kwakabatana nekudya. Inotarisa mTORC1 nzira yekusaina. Iyi nzira yakakosha pakukura kwesero uye lipid synthesis, nekudaro, kukonzeresa kuunganidzwa kwemafuta mumuviri.

 

Yakawanda sei fisetin yandinofanira kutora: The fisetin dosage?

Fisetin dosage inosiyana pakati pe2 mg kusvika ku5 mg, pakirogiramu yehuremu, zvisinei, iyi haisi iyo inokurudzirwa nhungamiro yedose. Iko hakuna kurudziro yekurudziro yekushandiswa kwefisetin, uye kutaura kune nyanzvi yekurapa kungabatsira mukuona fisetin dosage renji, yakanangana nemamiriro emunhu. Mune imwe yezvidzidzo zvakaitwa nechinangwa chekuongorora kushanda kwefisetin powder pakuputika kunokonzerwa nekenza yekoloni, 100 mg pazuva yaidiwa kuti ione kuderera kukuru kwekuputika.

 

Ndezvipi zvinokonzerwa nefisetin?

Fisetin nguva pfupi yadarika yakava nyaya yezvidzidzo zvakawanda uye zvidimbu zvakasiyana zvekutsvagisa. Uku kunonoka kufarira muflavonoid kunoreva kuti zvidzidzo zvakawanda zvakaitwa zvanga zviri pamhando dzemhuka kana mumarabhoritari. Hazvina zvakawanda zvidzidzo zvevanhu zvakaitwa kuti zvinyatsoona zvingangoitika mhedzisiro uye chepfu yekuwedzera. Mhuka dzemhando dzepakuratidzwa kune yakakwira madosi efisetin yekuwedzera haina kuratidza chero yakashata mhedzisiro, ichinongedza kune kuchengetedzeka kwekuwedzera.

Zvisinei, zvakakosha kuyeuka kuti kushayikwa kwemigumisiro mumhando dzemhuka hazvirevi kuti njodzi yemigumisiro muvanhu haipo. Kusvika pamhedziso iyoyo, zvidzidzo zvekiriniki zvakawanda zvinoda kuitwa. Mune imwe tsvakurudzo yakaitwa kune varwere vekenza kuti vaone kushanda kwefisetin powder mukugadzirisa zviratidzo zvekenza, zvose placebo uye mapoka ekutonga akarondedzera kusagadzikana kwegastric. Sezvo rutivi rwakanga rwuripo mumapoka ose maviri, uye mapoka ose ari maviri aiitwa chemotherapy panguva imwe chete, zvakaoma kugumisa kuti fisetin poda inoshandiswa inogona kukonzera kusagadzikana kwegastric.

Fisetin powder inogona kunge isina mimwe migumisiro yemigumisiro asi inopindirana nemamwe madhiragi, zvichiita kuti kuchinjwa kwemetabolism yemishonga iyoyo. Fisetin yakawanikwa ichideredza mazinga eshuga yeropa mumhando dzemhuka, izvo zvinobatsira kwazvo pachezvayo. Asi kana yakatorwa pamwe chete nemishonga inorwisa-chirwere cheshuga, iyo glucose-inoderedza mhedzisiro yezvose zviri zviviri, yekuwedzera uye mushonga zvinogona kuwedzeredzwa. Izvi zvinogona kukonzera matambudziko mazhinji ehutano.

Fisetin powder inogadziriswa nechiropa, nenzira imwecheteyo, iyo inoderedza ropa inogadziriswa. Pamusana peizvi, zvinofungidzirwa kuti vaviri ava vaizobatana uye Fisetin powder yaizowedzera migumisiro yeropa-thinning agents.

 

Fisetin poda uye fisetin zvinowedzera pamhepo

Fisetin poda inogona kutengwa pamhepo kubva kune vakasiyana fisetin poda vanogadzira, muhuwandu hunoenderana nezvinodiwa chaizvo. Kutenga fisetin yakawanda yakawanda inogona kubatsira nemitengo zvakare. Mutengo waFisetin hausi iwo wakabuda mumhando, uye uri mumutsara wakafanana nemamwe maflavonoid anowedzera.

Paunenge uchitsvaga kutenga fisetin yekuwedzera, zvakakosha kunyatsotarisa kuburikidza nevagadziri vefisetin hupfu uye maitiro avo ekugadzira. Izvi ndezvekuona kuti mirairo yekuchengetedza yakakodzera uye maprotocol ekugadzira anoteverwa panguva yekugadzirwa kwefisetin yekuwedzera. Izvo zvakakosha kutenga yakachena fisetin poda sezvo ichigadzira yakanakisa fisetin yekuwedzera. Kana mutengesi asingateveri mapuroteni ekuchengetedza muzvinyorwa uye synthesis yefisetin, iyo yekupedzisira-chigadzirwa chinogona kusvibiswa kana kusvibiswa nemidziyo inogona kunge ichikuvadza kuhutano hwevanhu kana kusakanganisa hutano hwevanhu, chero. Chero nzira, iyo fisetin mabhenefiti angadai asina kuwanikwa kunyangwe kutora iyo yekuwedzera kwenguva yakareba.

Nguva dzose zvakakosha kutarisa mukati mezvigadzirwa zvefisetin powder iri kutengwa uye chiyero chekugadzirisa kwezvinhu izvi kuti uone kuti yakachena fisetin powder iri kutengwa. Kana mutsauko uyu ukasaitwa, saka kune mukana wakakura wekuwedzera fisetin mhedzisiro uye / kana kuderedzwa mabhenefiti efisetin, zvakazara.

 

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261287/

https://pubmed.ncbi.nlm.nih.gov/29275961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780350/

https://link.springer.com/article/10.1007/s10792-014-0029-3

https://pubmed.ncbi.nlm.nih.gov/29541713/

https://pubmed.ncbi.nlm.nih.gov/18922931/

https://pubmed.ncbi.nlm.nih.gov/17050681/

https://pubmed.ncbi.nlm.nih.gov/29559385/