Oleoylethanolamide (OEA): Kurera Kurera Mushonga Unobatsira Kudzora Chido.

Chii chinonzi Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) ndeyezvisikwa mutongi wehuremu, cholesterol, uye chishuwo. Iyo metabolite inogadzirwa mune zvidiki zvidiki mumatumbu madiki. Iyo mamorekuru echisimba ndiwo anokonzera kunzwa kwekuzara mushure mekutora chikafu. Oleoylethanolamide inobatsira mukugadzirisa kwemafuta emuviri nekusunga kuPeroxisome proliferator-activated receptor alpha (PPAR-Alpha). Iyi yakasikwa metabolite inowedzera mafuta emuviri metabolism uye inozivisa uropi hwako kuti watora chikafu chakaringana uye unofanirwa kurega kudya. Oleoylethanolamide inowedzerawo isiri-yekurovedza zvine chekuita nekarori mari.

Oleoylethanolamide (OEA) Inoshanda Sei?

Oleoylethanolamide (OEA) Mechanism yekuita

Oleoylethanolamide (OEA) inoshanda se nzara yekudaira. Oleoylethanolamide inodzora kudya kwako kwekutumira nekutumira masaini kuuropi ichizivisa kuti iwe uzere, uye inguva yekumira kudya. Semhedzisiro, iwe unotora zvishoma chikafu pazuva, uye muviri wako unomira kurongedza humwe huremu munguva refu.

Oleoylethanolamide (OEA) (111-58-0) inogadzirwa uye inosimudzirwa mudumbu diki kubva kune oleic asidhi inotorwa kubva mukudya. Chikafu chine mafuta mazhinji chinogona kukanganisa chinogadzirwa Oleoylethanolamide mu proximal mudiki.

Oleoylethanolamide inoderedza chikafu chekudya nekusimudzira histamine uropi kutenderera, homeostatic oxytocin, uye hedonic dopamine nzira. Zviripachena kuti Oleoylethanolamide inogonazve kuisa signature yeCB1R, iyo kana yakakurudzirwa inogona kutungamira kuwedzera kudya kwekudya. Oleoylethanolamide inoderedza lipid kutakura kupinda adipocytes kuderedza mafuta masasi.

OEA zvakare inoshanda kukurudzira chimwe chinhu chinozivikanwa sePPAR uye panguva imwecheteyo chinodzikisira kuchengetedza mafuta uye kuwedzera kupisa kwemafuta. Chero iwe paunotora chikafu, mazinga eOEA anokwira uye nzara yako inodonha. Izvi zvinoitika nekuda kwekuti sensors nerves dzakabatana nehuropi hwako dzinozivisa kuti iwe uzere nekutenda kune PPAR-α. PPAR-α is ligand-activated nyukiliya receptor iyo inobatanidzwa mune simba homeostasis nzira uye gene expression ye lipid metabolism.

Oleoylethanolamide (OEA) inoratidza maitiro ese anotsanangura satiety factor inosanganisira:

• Kuvhiringidza kudya nekuwedzera nguva yekupindirana pakati pekudya kumwe kusvika pakudya kunotevera;
• Kugadzirwa kwayo kunodzorwa nekuwanikwa kwemafuta ezvirimwa
• Matanho ayo anoenderera zvinoyerera circadian.

Oleoylethanolamide (OEA) Anobatsirwa

Oleoylethanolamide zvakanaka uye uremu uremu mhedzisiro inosanganisira;

i. Kuderedza chishuvo chinomutsa chinonzi hormone chinonzi Ghrelin

Majekiseni ekuputika eOEA akapihwa kumakonzo ayo akange atsanya kwezuva rimwe chete hakuna kukanganisa pesero re ghrelin mukati memaminitsi zana nemakumi matatu, asi mushure memaawa matanhatu pakaderera zvinoshamisa muhormone iyi ne120 kusvika makumi mashanu muzana. Nekudaro, Oleoylethanolamide yakange isina mhedzisiro yekutaridzika kweichi chishuvo chinosimudzira mahormoni mune akapakurwa tsvimbo. Izvi zvinoratidza kuti OEA yekuwedzera inoshanda zvakanyanya mukuderedza mizhinji ye ghrelin kana ikatorwa pamberi pekudya.

ii. Kuwedzera chiyero chekurasikirwa kwemafuta emuviri

Iyo βeta-adrenergic receptors inoshanda kuti isimudzire huremu uye kukurudzira βeta3-adrenergic receptor inopa kudzikira kwekudya kwekudya uye kuwedzera mafuta kurasikirwa mumakonzo. Iyo receptor inodaro kuburikidza nekumutsa unplling mapuroteni anosanganisira UCP1.

Nekuda kweizvozvo, co-administration ye β3 agonist uye oleoylethanolamide peripheral jekiseni inoita kunge inoshanda mukudzora kudya kwekudya uye inoshanda mukuderedza mafuta mashoma ane chekuita nekukwira kwemashandisirwo esimba. Iko kukwira kwematanho eUCP1 uye PPARcy (inofungidzirwa kuratidza simba rekushandisa kusimuka) yakaitika mune ese ari maviri machena uye machena adipose tishu pamwe chete nekuwedzera mune mitochondrial biomarkers.

OEA saka inoita senge inowedzera iyo mitochondrial metabolism zvimiro uye zviitiko zvemoyo mumakonzo mune zvese brown uye chena adipose tishu, panguva imwechete olelelethanolamide dosage seiya yaishandiswa kudzora chishuwo.

III. Kuderedza Chikamu chePeptide YY (Chidyo-chinosimudzira Hormone)

Majekiseni e5mg / kg Oleoylethanolamide kumakonzo akakonzera kuderera-kunoenderana nenguva muhormone peptide YY inogadzirwa mumatumbu mune zvese zvakadyiwa uye chikafu-chinoshaya nyika.

Ko Oleoylethanolamide (OEA) Inobatsira Kudzora Chidimbu?

Ehe. Oleoylethanolamide uremu kuwedzera huremu inowedzera kubatsira kudzora chishuwo nekumisa PPAR nekudaro kuderedza kuchengetedza kwemafuta uye kuwedzera kupisa kwemafuta. Paunotora kudya kwako, Oleoylethanolamide mazinga anomuka uye yako yekudya yakaderera apo zvikwangwani zvinotumirwa kuuropi hwako zvichizivisa uropi kuti waguta.

Pave paine zvinoverengeka zvidzidzo zvesainzi zvinoratidza izvi. Muna 2004, semuenzaniso, vaDenmark vatsvaguru vakadzidza makonzo akapihwa chikafu chezuva rimwe. Vakavapa OEA uye vakaziva kuti huwandu hwezvikafu zvavakatora zvakaderera ne15.5%. Mune mazwi akareruka, Oleoylethanolamide (OEA) anodzima switch yekuenzara mu CNS (Central Nervous System).

Oleoylethanolamide (OEA) Chipimo chemushonga

Iyo yakakurudzirwa oleoylethanolamide dosage imwe kapeturu 200mg kana inotorwa pasina musanganiswa. Kana ikasanganiswa nezvimwe zvinoremerwa nekuremerwa uremu, OEA dofo inofanira kuderedzwa kusvika pakati pe100mg kusvika 150mg.

Zvinokurudzirwa kuti utore oleoylethanolamide kuwedzera maminitsi makumi matatu usati wadya kana kudya kwemangwanani; iwe unonzwa uchinyatsogutsikana panguva yako yekudya uye pakupedzisira uchitora zvishoma zvekudya.

Tsvagudzo inoratidza kuti iwe unogona zvakare kuderedza kana kuwedzera zuva nezuva dosage zvinoenderana nehuremu hwako. Semuenzaniso, kana iwe uchirema 150lb, unogona kutora 100mg. Munhu 200lb anogona kutora 150mg uye munhu 250lb anogona kutora 180mg yeimwe yekuwedzera.

Oleoylethanolamide (OEA) Side Migumisiro

Oleoylethanolamide madhara inogona kuve yekunetseka kukuru pakati pevagadziri vekuwedzera avo vanoda kusanganisira ichi chinesimba mune yavo yekuwedzera uremu kurasikirwa formula.

Mushure mekutarisirwa kwakadzama kwese kwese kuwanikwa data resainzi, iyo US FDA (Chikafu neDoro Dhizaini) haina nyaya nezvekuchengeteka kweiyi molekyuli yakasikwa. RiduZone yaive yekutanga OEA powder kuve yakaiswa chiratidzo muna 2015.

OEA ndeye oleic acid metabolite uye chikamu chechikafu chezuva nezuva chine hutano. Izvo zvakachengeteka zvachose kutora Oleoylethanolamide supplement sezvo pasina zvakakomba mhedzisiro mhezi zvave kusvika pari kutaurwa.

Oleoylethanolamide (OEA) Tenga

Unogona kuwana oleoylethanolamide kutenga kubva kune dzinoverengeka online uye epanyama zvinodhaka zvitoro. Iwe unozofanirwa kuchenjera nekuti havasi vese vanopa zvinhu vari vechokwadi. Ita shuwa kuti iwe uverenge yavo oleoylethanolamide ongororo kuti uzive icho chiitiko chevatengi vavo vepakutanga chaive chii.

Iwe uri kushamisika pane kwaunowana oleoylethanolamide yekutengesa? Usanetseka; unogona kutenga oleoylethanolamide online pano pane yedu webhusaiti. Isu tiri vanhu vane mbiri uye vane ruzivo OEA mutengesi uye isu tinokwanisa kununura Oleoylethanolamide (OEA) muU.SA nedzimwe nyika dzinoverengeka pasirese. Maitiro edu ekuraira ari nyore asi akachengeteka zvakakwana uye akachengeteka. Isu tinopawo zvigadzirwa zvedu mumasunga akavharika uye akajeka mapakeji kuona kuchengetedzeka uye kudzivirira chero kusvibiswa.

Chirevo ne:

Dr. Liang

Co-muvambi, yekambani manejimendi manejimendi manejimendi hutungamiriri; PhD inogamuchirwa kubva kuFudan University mune organic chemistry. Anopfuura makore mapfumbamwe ezviitiko mu organic synthesis munda wemushonga kemisitiri. Hupfumi ruzivo mukubatanidza kemesitiri, mushonga wemakemikari uye tsika synthesis uye manejimendi manejimendi.

References:

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• Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Postprandial kuwedzera kwe oleoylethanolamine kuunganidzwa mune dumbu ura hweBurmese python (Python molurus)". Ndiri J Physiol Regul Yakabatana Yakabatana Physiol. 290 (5): R1407 – R1412.
• Sarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. Brain mamorekuru uye kusadya: nyaya ye oleoylethanolamide. Central Nervous System Agents muMedical Chemistry. 2013; 13 (1): 88-91.
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