Wisepowder ine huwandu hwakazara hwezvigadzirwa zvechirwere cheAlzheimer, uye ine huwandu hwese hwehutongi hwehurongwa

Chii chinonzi Alzheimer's Disease?

Chirwere cheAlzheimer ndechimwe chezvikonzero zvinowanzoitika zvekuremara muhuwandu hwevanhu vakwegura. Icho chirwere chetsinga icho chinofambira mberi chinokonzeresa kudzikira kwemasuru ehuropi uye kutanga kweiyo neuronal degeneration. Ndiyowo nzira yakajairika yedementia, inoguma nekusashanda zvakanaka mundangariro, hunyanzvi hwemagariro, kufunga, uye maitiro. Pasi rose, vanhu vanopfuura mamirioni makumi matatu vanopfuura makore makumi matanhatu nemashanu vanotambura nechirwere cheAlzheimer.
Varwere vanotambura nechirwere cheAlzheimer pakutanga vanoratidza zviratidzo zvekurangarira kwakashata sekutadza kuyeuka zviitiko zvichangoburwa. Nekuwedzera kwechirwere, chirwere cheAlzheimer chinogona kukonzera kukanganisika kwakanyanya kwendangariro. Pakupedzisira, murwere anenge asingakwanise kuita kunyange zviitiko zvekutanga zvehupenyu hwezuva nezuva sekuzvipfekedza, kudya, kubvisa ura hwavo, zvichingodaro.

Ndeupi musimboti etiology weAlzheimer's Disease?

Iyo yekumberi etiology yechirwere cheAlzheimer haisati yanyatsonzwisiswa zvakajeka. Asi, vazhinji nyanzvi mune ino ndima vanotenda kuti kusagadzikana muprotein yeuropi kunokonzera cheni yezviitiko zvinokonzeresa kufa uye kukanganisa kushanda kwehuropi. Zvidzidzo zvinoratidza kuti chirwere cheAlzheimer chine multifactorial etiology, nemajini, mararamiro, uye nharaunda zvinobatsira mukukudziridza kwechirwere cheAlzheimer.
Muzviitiko zvisingawanzoitika, shanduko yemageneti inoita kuti munhu atapurirwe neAlzheimer's. Mune dzakadai shanduko-inokonzereswa zviitiko, kutanga kwezviratidzo kunoitika pakutanga uye kufambira mberi kwacho zvakare kunokurumidza.
Kazhinji, chirwere chinotangira muchikamu chehuropi uko ndangariro dzinoumbwa. Asi chirwere chaicho chinotanga nguva refu murwere asati atanga zviratidzo. Muchikamu chepamusoro chechirwere, uropi hunova atrophied zvinoshamisa. Kunyanya, mapuroteni maviri akabatanidzwa muchirwere cheAlzheimer, Beta-amyloid protein, uye Tau mapuroteni.

Mapikicha

Beta-amyloid ipuroteni yekutanga inogona kuve inotyisa kune mauroni kana ikasangana muuropi. Masumbu ezvimedu zve beta-amyloid anogona kukanganisa nzira yekutaurirana pakati pemasero. Kana masumbu aya akaumbana pamwe chete, nei uchigadzira chimiro chakakura chinozivikanwa seamyloid plaques.

Tangles

Kune mashandiro akanaka emauroni, tau mapuroteni akakosha kutakura zvinovaka muviri uye zvimwe zvinhu zvakakosha kutsigira zvemukati mauroni. Kana mapuroteni eTau akarongedzazve kuita matangi anonzi maurofibrillary tangles, anogona kukonzera chirwere cheAlzheimer. Aya tangles anogona kukonzera kukanganiswa kwekutakura kweiyo manyuturoni kumaeuron, zvichikonzera kufa kwavo.

Njodzi Zviitiko zveAlzheimer's Disease

Pane zvinhu zvinoverengeka zvinogona kuwedzera njodzi kuAlzheimer's disease, idzo dzakanyorwa pazasi.

zera

Zera ndiyo inonyanya kukosha yengozi yekukura kwedementia, kusanganisira chirwere cheAlzheimer. Nekudaro, Alzheimer's haisi chiratidzo chekweguru uye haisi yekujairika kuwana.

Genetics

Kana nhengo yepedyo yemhuri yako yakamboonekwa kuti ine Alzheimer's, njodzi dzeAlzheimer dzakakwirira kupfuura huwandu hwevanhu.

Down chirwere

Varwere vanozvarwa vaine Down syndrome, chromosomal disorder, vanokanganisa chirwere cheAlzheimer vachiri vadiki. Kazhinji, ivo vanokudziridza Alzheimer mune yekutanga kana yechipiri gumi ehupenyu.

Kutambudza Bongo Kukuvadza

Nhoroondo yekutambudzika kwakanyanya kwemusoro kunogona kuwedzera njodzi yako yekuvandudza chirwere cheAlzheimer. Zvidzidzo zvakaratidza kuti pane chiitiko chakawedzera cheAlzheimer muvanhu vane chiitiko chekukuvara kwehuropi.

Kunwa doro

Kunwa doro kunogona kukonzera shanduko dzisingaperi kuuropi. Dzidzo hombe-dzakakura dzakaratidza kuti kunwa doro kunosanganisirwa ne dementia.

kutadza kurara

Matambudziko ekurara, akadai sekushaya hope, akave zvakare akabatanidzwa nekuwedzera zviitiko zveAlzheimer muzvidzidzo zvakakura.

Lifestyle

Zvinhu zvine njodzi yezvirwere zvevascular vascular zvakadai sokufutisa, hypertension, high cholesterol, kusvuta, uye chirwere cheshuga zvakabatanidzwawo nehosha yeAlzheimer.

Zviratidzo uye Zviratidzo

Zvinozivikanwa kuti chiratidzo chikuru chechirwere cheAlzheimer kurasikirwa ndangariro. Mumatanho ekutanga echirwere, varwere vane matambudziko nekurangarira ndangariro dzichangobva kuitika uye zviitiko. Nekufambira mberi kwechirwere, zvine chekuita neyekurangarira uye kugona kwekuziva.
Kufungirwa kwekuora mwoyo kwekutanga kunotanga kubva kushamwari dzepedyo kana nhengo dzemhuri apo zviratidzo zvinowedzera zvakanyanya kuti zvionekwe. Kuchinja kwehutachiona kumatumbu ehuropi kunopa kiriniki seinotevera.

Matambudziko Ekurangarira

Sekurasikirwa kwekurangarira kuchikura nechirwere cheAlzheimer, vanhu vane nyaya nekutaurirana kwemazuva ese sekukanganwa hurukuro, kuisa zvisirizvo zvinhu kazhinji, kurasika munzvimbo dzinozivikanwa, uye kuva nenyaya dzekupa mazita zvinhu kana kutaura kwekufunga.

Hunhu Kuchinja

Alzheimer's inogona kushandura zvakanyanya hunhu hwemunhu uye maitiro. Hunhu hwaimbofara hunogona kuchinja kuita kushushikana kwepfungwa uyezve uchiratidza kushaya hanya, kushanduka kwemweya, uye kurega kushamwaridzana.

Zvakaoma kuita sarudzo

Varwere vane Alzheimer vane dambudziko mukuita kutonga kwakanaka uye sarudzo. Semuenzaniso, murwere anogona kuzvibata asina hunhu mutsika dzevanhu sekufamba mumvura kana kuseka panguva yemariro.

Dambudziko nemabasa akajairwa

Alzheimer's inogona kukanganisa kugona kwemunhu kuita zvakajairika zviitiko sekubika, kutyaira, kutamba mitambo, zvichingodaro. Sezvo chirwere ichi chichienderera mberi, murwere anogona kurasikirwa nekwaniso yekuita zviitwa zvezuva nezuva sekuzvipfekedza uye angatoregeredza hutsanana hwavo.

Matambudziko nekufunga

Abstract kufunga uye pfungwa zvakanyanyisa kuomarara kune vanhu vane chirwere cheAlzheimer nekuda kwematambudziko nekufungisisa. Varwere vanogona zvakare kuve nematambudziko mukuita akawanda mabasa panguva imwe chete. Zviitiko zvezuva nezuva zvakakosha pakurarama senge manejimendi emari zvinogona kuita zvisingaite kune varwere vane Alzheimer's.

Chirwere cheAlzheimer chinoonekwa sei?

Vazhinji varwere vanoziviswa nezve zviratidzo zvavo neshamwari yepedyo kana nhengo yemhuri, mushure meizvozvo murwere anowanzo tsvaga kurapwa. Mimwe miedzo inofanirwa kuitwa kuti isimbise kuongororwa kweAlzheimer's. Iyi bvunzo inogona kusanganisira kuongororwa kwendangariro yemurwere uye hunyanzvi hwekuziva, uye kumwe kuyedza kwekufungidzira. Kufungidzira uye kuyedza kwerabhoritari kwakakosha kutonga kusiyanisa kuongororwa kweAlzheimer's. Nekudaro, kuongororwa kwekusimbiswa kweAlzheimer's kunowanzoitika mushure mekufa kwemurwere sezvo kuongororwa kwake kwehutachiona hwehuropi kunoratidza shanduko dzakadai senge neurofibrillary tangles uye amyloid plaque.
  • Kuongorora Kwepanyama: Kuti utonge zvimwe zvinokonzeresa kuora mwoyo, chiremba anoongorora mafungiro ako, gait, simba remhasuru uye matauriro, mashandiro emitsipa, chiyero, nekubatana.
  • Kuongorora kwerabhoritari: Kunyange kuongororwa kweropa kusingakwanise kusimbisa kuongororwa kweAlzheimer's, zvakakosha kuti ubvise hutachiona, mamota, kana kushomeka kwevhitamini, zvese izvi zvinogona kukonzera zviratidzo zvakafanana neAlzheimer's. Mune zvimwe zviitiko zvisina kujairika, kuongororwa kwecerebrospinal fluid inogonawo kuitwa.
  • Neurological Testing: Kuongororwa kwechimiro chepfungwa kunosanganisira kuongororwa kwehunyanzvi hwekufunga, ndangariro, uye cognition. Iyo bvunzo inofanidza kugona kwekuita nyore kunzwisisa uye ndangariro-yakavakirwa mabasa nevamwe vanhu vezera rakaenzana pasina chero mamiriro ehutano.
  • Kufungidzira zvidzidzo: Brain scan neMRI kana CT yakakosha pakuongorora chirwere cheAlzheimer's. Izvi zvidzidzo zvekufungidzira zvinogona zvakare kubatsira kuziva zvimwe zvikonzero zvekuchinja mumamiriro epfungwa senge ischemic sitiroko, kubuda ropa, mamota, kana kushungurudzika. Brain shrinkage uye nzvimbo dzekusagadzikana kwemetabolism zvinogona kutaridzika kuburikidza nedzidzo dzekufungidzira. Mamiriro matsva ekufungidzira achishandisa PET scan, amyloid PET imaging, uye Tau PET imaging ari kutsvagirwawo nezvebasa ravo mukuongorora Alzheimer's.
  • Plasma Aβ: Plasma Aβ kuongororwa kweropa kunoshandiswa kuwedzera kusimbisa kuongororwa kweAlzheimer's. Iyo bvunzo ichangobvumidzwa muUS uye inowanikwa pari zvino.
  • Mageneti Miedzo: Kunyangwe kuongororwa kwemajini kusingawire pasi peongororo yeAlzheimer's, avo vane hama dzekutanga-degree vanotambura neAlzheimer's vanogona kuongororwa majini.

Ndezvipi Zvinetso zveAlzheimer's?

Izvo zvinetso zvinosangana neAlzheimer's zvakafanana neclinic mharidzo. Nyaya dzendangariro, mutauro, uye kutonga zvinogona kuomesa hupenyu hwemurwere uye kutokanganisa kugona kwavo kutsvaga kana kurapwa. Kusakwanisa kutaura marwadzo, zviratidzo, kana kutevera kurapwa kunogona zvakare kukuvadza kosi yechirwere.
Mumatanho ekupedzisira echirwere, huropi atrophy uye maseru shanduko zvinogona kukanganisa zvakajairika mashandiro. Murwere anogona kurasikirwa nekwaniso yekudzora ura uye kufamba kwedundira, uye anogona zvakare kuve nematambudziko nekumedza. Mamwe matambudziko anosanganisira kusangana kwezvirwere, kuwedzera kwezviitiko zvekudonha, kushomeka kwezvokudya zvinovaka muviri, kupera mvura mumuviri, uye ura kuchinja.

Ko Alzheimer's Inogona Kudziviswa?

Nehurombo, humbowo hwazvino hunoratidza kuti kudzivirira chirwere cheAlzheimer hazviite. Asi, kunzvenga njodzi dzinosangana neAlzheimer's kunogona kubatsira kugadzirisa kosi yechirwere uye kudzikisira mukana wekutambura neAlzheimer nekuwedzera zera. Nekuita mararamiro ane hutano sekuita zuva nezuva kurovedza muviri, kushandisa chikafu chakaguta nemiriwo nemichero, kuongororwa kwehutano nguva dzose, kuchengetedza kuwedzerwa kweropa uye cholesterol mumazinga, kudzivisa zvinokuvadza zvinokuvaraidza zvakaita sedoro kana fodya zvingangobatsira mukuchengetedza ndangariro nekuziva basa gare gare muhupenyu. Zvakare, kutora chikamu mune zviitiko zvinoda kufunga uye kubatika kweakakwira epfungwa mashandiro sekutamba chess, kugadzirisa maths matambudziko, kana kutamba mitambo yakaoma kunogona kubatsira kuchengetedza mabasa epfungwa nezera riri kuwedzera.

Kurapa kweAlzheimer's Disease

Zvinodhaka izvo zvirikushandiswa kurapa rubatsiro rweAlzheimer nezviratidzo. Ivo havachinje iyo kosi yechirwere kana kurapa mamiriro acho. Kunyanya, mhando mbiri dzemishonga parizvino dzakatemerwa Alzheimer's.

Cholinesterase inhibitors

Muchirwere cheAlzheimer, pane kupera kweacetylcholine, inova neurotransmitter, yakave yakabatanidzwa muchirwere chechirwere. Naizvozvo, kuvharirwa kwemakemikari anoputsa acetylcholine kunogona kubatsira pakurapa kweAlzheimer's.
Cholinesterase inhibitors inowedzera iwo mazinga eiyo neurotransmitter, Acetylcholine nekudzivirira kuparara kwayo. Iwo ndiwo ekutanga mushonga wesarudzo mune vese varwere vachangobva kuongororwa vane chirwere cheAlzheimer uye vanogona kuzvininipisa kugadzirisa zviratidzo. Kazhinji cholinesterase inhibitors anoshandiswa pakurapa chirwere cheAlzheimer ndeye galantamine, rivastigmine, uye donepezil.

Anopikisa weNMDA

Memantine, anopikisa weNMDA anoshandiswawo pakurapa chirwere cheAlzheimer. Inonyanya kushandiswa mune avo varwere vasingakwanise kutsungirira kurapwa neCholinesterase inhibitors. Iko kune mwero kuvandudzwa kwezviratidzo kana uchirapwa ne memantine. Nepo kurapwa kwakabatanidzwa kwemememine pamwe nemamwe cholinesterase inhibitors hakuna kuratidzwa kuve kunobatsira, zvidzidzo zviri kuitiswa kuti zvione chero zvingabatsire.

Alternative medicine

Mazhinji mavitamini, ekuwedzera, uye mahebhu anoshandiswawo kune varwere vane chirwere cheAlzheimer sezvo chingave chinobatsira mukuvandudza kugona kwekuziva. Zvidzidzo zvinoongorora mabhenefiti emishonga iyi hazvisati zvichizivikanwa. Mamwe marapirwo anogona kubatsira ndeaya:

9-Me-BC Poda

9-ME-β-Carbolines ndiwo pyridoindole macomputer, ayo akawanikwa kubva kune ese endogenous nzira uye dzekunze nzira. Kutsvagurudza pa9-ME-β-Carbolines kwaona kuti izvi zvinokomberedza zvinogona kupa zvinobatsira zvakadai seuroprotection, neurostimulation, anti-inflammatory action, uye neuroregeneration. Uyezve, 9-ME-BC yakadzivirira kuwanda kwedopaminergic neurons pasina kukanganisa dopamine kutora. 9-ME-BC yakaratidza anti-kuwanda zviito zvine mashoma mashoma mahedheni mhedzisiro.
Zviito zve9-ME-BC zvinopindirana neye organic cation mutakuri, uye zvakare zvinokonzeresa kutaura kwemajini anokonzeresa kubatanidzwa kwezvakawanda zvakakosha zveurotrophic zvinhu zvinosanganisira BDNF, NCAM1, uye TGFB2. Izvi zveeurotrophic zvinhu zvakakosha pakubuda kwemaurite, ayo anogona kuve neurodegenerative uye neuroprotective mabhenefiti apo maNeuron ari kusangana neakasiyana maturu. Nekudaro, 9-ME-BC ine mabhenefiti mazhinji pane mauroni ayo anoita kuti ive inobatsira kuwedzera pakurwisa kwetsinga dzakadai sechirwere chePasinson nechirwere cheAlzheimer.

CMS121 Poda

CMS121 yakabva mufisetin inonzi neuroprotective compound iyo inoshandiswa nemuromo. Fisetin chinhu che flavonoid chinobva pamichero nemiriwo. Zvidzidzo zvakaratidza kuti fisetin ine zvinobatsira pamhedzisiro uye kutaurirana kweeuronal. Pamwe pamwe neayo antioxidant zvivakwa, fisetin inogona zvakare kuwedzera mwero weeuroprotective zvinhu mukati meCentral Nervous System. Uyezve, fisetin inewo anti-inflammatory properties. Ese aya mabhenefiti efisetin anoratidza kuti zvinogona kubatsira pakurapa kwezvirwere zvine mhirizhonga mukutaura kweeuronal nekushanda.
Izvo zvinobva kune fisetin, CMS121 powder ine 400 nguva yakakwirira kupfuura fisetin. CMS121 zvakare yakaratidza zvimwe zvivakwa senge kuvandudzwa kweiyo pharmacological chimiro uye kugadzikana muchimiro chayo chemuviri nekunaka kwemuromo bioavailability. CMS121 inogona kunge iri yekuwedzera inowedzera mune varwere vane chirwere chetsinga senge chirwere cheAlzheimer.

CAD31 upfu

CAD31 ine akawanda anobatsira mhedzisiro angave anoshanda mukudzora kudzora zvine chekuita nezera kweeuroni. Izvo zvakaratidzirwa kukurudzira maseru emadzinde akatorwa kubva mumbeu dzevanhu kutevedzera. Kuedza kuyedza mabhenefiti eCAD31 mune yekiriniki mamiriro akaitwa muzvidzidzo zvemhuka. Mice mhando dzine chirwere cheAlzheimer dzakapihwa neCAD31. Chidzidzo chakacherekedza kuvandudzwa kwemabasa ekurangarira uye kuderera kwekuzvimba mumakonzo emhando. Yakagumisa kuti CAD31 inogona kuve neuroprotective uye zvakare inokwanisa kuyambuka iropa-yeuropi chipingaidzo zvinobudirira.
CAD 31 inonyanya kuita kuburikidza nekuumbwa kweiyo synapses uye tarisa metabolic nzira senge metabolism yemafuta acids. Izvi zvidzidzo zvepakutanga zvine zvivimbiso zvekuwanikwa kwekushandisa kweCAD-21 mumatambudziko emitsipa anosanganisira chirwere cheAlzheimer uye mamwe marudzi ehusimbe hwekuora mwoyo.

J147 upfu

J147 powder inotorwa kubva kuCurcumin, iyo pachayo inouya kubva kune inozivikanwa Indian spice inozivikanwa sekuti turmeric. Curcumin ikomboni ine inozivikanwa-inobatsira mhedzisiro senge inorwisa-kupisa zvivakwa, antioxidant mhedzisiro, kudzora amyloid protein-inoshatisa huturu, zvichingodaro. Nehurombo, iyo curcumin pachayo yanga isiri yekuwedzera inowedzera sezvo iine hurombo hwakanyanya bioavailability uye isingakwanise kuyambuka ropa-huropi chinodzivirira futi.
Kusiyana necurcumin, J147 powder ine yakanyanya kugadzikana pharmacological chimiro, yakanaka CNS yekupinda, uye zvakare ine yakanaka yemuromo bioavailability. J147 molecule zvakare ine inopfuura kagumi simba rakanyanya pakuenzanisa necurcumin. Zvidzidzo zvemhuka zvakaitiswa kusvika pari zvino paJ10 powder zvakaratidza kuti zvinogona kubatsira zvakanyanya muvanhu vakwegura uye mune avo vanotambura nechirwere cheAlzheimer.

Monosialotetrahexosyl ganglioside Sodium (GM1) upfu

Monosialotetrahexosylganglioside sodium (GM1) chinhu chinonyanya kufarirwa chinoshandiswa kurapa kusagadzikana kwetsinga. Izvi zvinonyanya kukonzerwa neyeuroprotective chiito. Asi zvakare ine zviito zvinobatsira zvekuchengetedza pamidziyo yeropa inopa iyo CNS. Muchidzidzo chakaitwa paGM1 compound, GM1 yakawanikwa iine zviito zvekudzivirira pane mahara radicals inokonzerwa nekukuvara kwesero.
Iyo neuroprotective, pamwe neiyo antioxidant zvivakwa zveMonosialotetrahexosyl ganglioside Sodium (GM1) poda, inoita kuti ive mukana unobatsira wekuwedzera kweakawanda matambudziko epakati ehurongwa hwehurongwa kusanganisira asi husingaganhurwe nechirwere cheAlzheimer, chirwere chaPasinson, chirwere cheshuga cheshungu, zvichingodaro.

Octacosanol upfu

Octacosanol chinhu chemakemikari chinowanikwa kubva kuzvirimwa senge gorosi germ mafuta uye shuga. Zvayakaumbwa uye zvemakemikari, ine zvimiro zvakafanana neVitamin E. Ongororo dzinoverengeka dzakawana octacosanol kuva ne antioxidant, neuroprotective, uye anti-inflammatory properties. Inoshandiswa zvakanyanya nevatambi uye zvakare inoshandiswa sechibatiso mukurapa kwehutano hwepfungwa senge chirwere chePasinson, chirwere cheAlzheimer, chirwere chaLou Gehrig, uye zvimwe zvakawanda.

Kuenderera Mberi Zvidzidzo PaAlzheimer's Disease

Iko hakuna kurapwa kwechirwere cheAlzheimer parizvino, uye mishonga yese irikushandiswa pakurapa kwechirwere cheAlzheimer inogona chete kugadzirisa zviratidzo kwechinguva nekusimudzira chiitiko chemaurotransmitter mukati meiyo yepakati system system. Asi iyi mishonga haigone kudzivirira chirwere kubva mukufambira mberi.
Zvidzidzo zvakawanda zviri kuitiswa kuti unzwisise zvirinani chirwere chechirwere etiology uye pathophysiology kukudziridza tarisiro yekurapa kweAlzheimer's. Vatsvagiri mune ino ndima vanotarisira kuwana nzira dzekurapa dzinogona kunonoka kana kutomisa kufambira mberi kwechirwere kusvika padanho repamberi. Zvingangodaro kuti maitiro ekurapa mune ramangwana haazosanganisi mushonga mumwe chete, asi musanganiswa wemishonga yakawanda inoshanda munzira dzakawanda.

Kufungidzira kweAlzheimer's Disease

Nepo mishonga yakati wandei ichishandiswa kurapa chirwere cheAlzheimer, vanogona kungodzora kufambira mberi kwechirwere. Nekudaro, iyi mishonga ichiri yakakosha sezvo ichivandudza kugona kwemurwere kuzvimiririra uye kuita kwavo kwezuva nezuva nerubatsiro rudiki. Mabasa akasiyana siyana aripo anopa rubatsiro kuvarwere vane chirwere cheAlzheimer. Zvinosuruvarisa, hapana mushonga unozivikanwa wechirwere cheAlzheimer.

Dheuteronomio:

  1. Gruss M, Appenroth D, Flubacher A, Enzenperger C, Bock J, Fleck C, Gille G, Braun K. J Neurochem. 9 Jun; 2012 (121): 6-924.
  2. Ates G. Redox Biol. 121 Sep; 2020: 36. doi: 101648 / j.redox.10.1016. Epub 2020.101648 Jul 2020. PMID: 21; PMCID: PMC32863221.
  3. Daugherty D, Goldberg J, Fischer W, Dargusch R, Maher P, Schubert D. Nhaurwa yeAlzheimer's chirwere chemushonga chinodenha chinotarisa kuzvimba uye mafuta acid metabolism. Alzheimers Res Ther. 2017 Jul 14; 9 (1): 50. doi: 10.1186 / s13195-017-0277-3. PMID: 28709449; PMCID: PMC5513091.
  4. Clarkson GJ, Farrán MÁ, Claramunt RM, Alkorta I, Elguero J. Chimiro cheanorwisa-kukwegura mumiririri J147 inoshandiswa pakurapa chirwere cheAlzheimer. Acta Crystallogr C Yakagadzirwa Chem. 2019 Kurume 1; 75 (Pt 3): 271-276.
  5. Shi M, Zhu J, Deng H. Clinical Hunhu hweInravenous Injection yeMonosialotetrahexosyl Ganglioside Sodium-Yakabatana Guillain-Barre Syndrome. Front Neurol. 2019 Kurume 15; 10: 225.
  6. Snider SR. Octacosanol muparkinsonism. Ann Neurol. 1984 Zvita; 16 (6): 723. doi: 10.1002/ana.410160615. PMID: 6395790.
  7. Guo T, Lin Q, Li X, Nie Y, Wang L, Shi L, Xu W, Hu T, Guo T, Luo F. Octacosanol Inotadzisa Kuzvimba mune ese RAW264.7 Macrophages uye Mouse Model yeColitis. J Agric Chikafu Chem. 2017 Chivabvu 10; 65 (18): 3647-3658.
  8. Sangano reAlzheimer. 2016 Alzheimer's chirwere chokwadi uye manhamba. Alzheimers Dement. 2016 Kubvumbi;12(4):459-509.
  9. Mantzavinos V, Alexiou A. Biomarkers yeAlzheimer's Chirwere Kuziva. Curr Alzheimer Res. 2017; 14 (11): 1149-1154. doi: 10.2174 / 1567205014666170203125942. PMID: 28164766; PMCID: PMC5684784.

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